Laois man visits Kenya to help marginalised and vulnerable communities

first_img Twitter Facebook By James Moore – 14th November 2019 Kelly and Farrell lead the way as St Joseph’s claim 2020 U-15 glory Twitter Pinterest Pinterest GAA Facebook Home News Community Laois man visits Kenya to help marginalised and vulnerable communities NewsCommunityLifestyle GAA Previous articleIn Pictures: Laois turns white as first snowfall of Winter 2019 hitsNext articleLaois library to get service to benefit people with dementia, autism and learning difficulties James Moore Here are all of Wednesday’s Laois GAA results WhatsApp WhatsApp TAGSIrish MissionariesKenyaMisean Cara Laois man Larry O’Loughlin recently visited Kenya as part of a mid-term strategic review of Misean Cara – the umbrella body for Irish Missionaries across the world involved in community development.Misean Cara is an international and Irish faith-based missionary movement working with some of the most marginalised and vulnerable communities in developing countries.They are working to realise their human rights through delivery of basic services in the areas of education, health, livelihoods and income generation, as well as advocacy, networking and community mobilisation.Misean Cara has 91 Missionary Members including Loreto Sisters, Kiltegan Fathers, Jesuits and many more. In fact almost all Missionary Societies from Ireland working in developing countries around the world.During his time in Kenya, Larry visited the Loreto Sisters project in Kitui, Kenya. Their most impressive initiative is called Nyumbani Village Project .It looks after over one thousand orphaned children who’s parents have died from HIV Aids. In many cases where grandparents are still alive, they too are accommodated in the village.All children receive full primary and secondary education within the campus. There is also a technical school which prepares the students for work in the local region.All the heath, recreational and spiritual needs of the children and grandparents are also looked after. There is also a farm within the Village which supplies the food needs of all the children and grandparents.The manager of the village project is a Mountmellick born Loreto nun Sr. Mary Owens who’s father worked in the National bank in Mountmellick in the 1950’s.Misean Cara, through Irish Aid, fund one of the Water catchment lakes which supply badly needed water on a year round basis for plant and vegetable irrigation as well as providing water for households.Larry also visited a Jesuit run Diploma program in Nairobi. This educates community leaders from Mombasa in mediation and conflict resolution among communities affected by mining industries.This project is again funded by Misean Cara. He also attended the annual meeting of all Misean Cara members operating in Kenya.This meeting was also attended by the Irish Ambassador to Kenya Ambassador Fionnuala Quinlan who praised the great work being done in community development all across Kenya by many Irish Missionary Societies.Speaking about the trip, Larry said: “These people truly do incredible work.“Sr Mary Owens is an amazing woman and it was a privilege to get to meet her.”Larry O Loughlin and Sr. Mary OwensAt the Misean Cara members meeting in Nairobi were Sr. Catherine Gleeson ; Ambassador Fionnuala Quinlan ; Misean Cara Director Larry O’Loughlin and Misean Cara Safeguarding Officer Valerie Philpott.SEE ALSO-REVEALED: Proposed opening date as works continue on new Supermacs Plaza in Portlaoise Laois man visits Kenya to help marginalised and vulnerable communities 2020 U-15 ‘B’ glory for Ballyroan-Abbey following six point win over Killeshin GAA RELATED ARTICLESMORE FROM AUTHORlast_img read more

Olypmic Cyclist Ricardo Lynch is New Face of Energy Conservation Campaign

first_imgRelatedOlypmic Cyclist Ricardo Lynch is New Face of Energy Conservation Campaign RelatedOlypmic Cyclist Ricardo Lynch is New Face of Energy Conservation Campaign Olypmic Cyclist Ricardo Lynch is New Face of Energy Conservation Campaign UncategorizedOctober 3, 2008 RelatedOlypmic Cyclist Ricardo Lynch is New Face of Energy Conservation Campaigncenter_img FacebookTwitterWhatsAppEmail Minister of Energy, Clive Mullings, has expressed delight at the decision by the Petroleum Corporation of Jamaica (PCJ), to name Olympic cyclist, Ricardo Lynch, as the face of their Energy Conservation Campaign.“We are very happy to have Ricardo as the face of conservation and energy, he epitomises what we need in this country, and he epitomises the fact that we can beat the world and solve our problems in one sweep,” Minister of Energy, Clive Mullings, stated at the recent signing of the Energy Conservation Contract, at the PCJ Building.“Ricardo represents the values that we should extol in our young people and we will put forward his image and voice for conservation and energy in Jamaica,” he further stated, adding “not many people realise that so much energy is put out by this young man that he can literally light up a light bulb”.At the 2008 Olympic Games in China, Ricardo Lynch, became the first Jamaican cyclist in 16 years to compete at an Olympics. He represented the country in the Kierin, an eight-lap event, which covers 2,000 metres on a 250-metre track. Mr. Lynch, who placed 17th out of 25 competitors, has promised to return to the Olympics in 2012 and do an even better job.“I want to express my thanks and appreciation for the confidence that was demonstrated in my ability to take home a medal for Jamaica, which was not possible at this time but I promise you in 2012, I will do everything in my power to bring this home,” he passionately expressed.Echoing the Minister’s sentiments of the appropriateness of having Mr. Lynch on board as an ambassador for energy, was Group Managing Director at the PCJ, Dr. Ruth Potopsingh, who stated that she was very excited at the prospects of what can be achieved through the partnership.“The PCJ has had a programme of energy efficiency and conservation for a number of years but we have always doubted the impact of this programme but with Ricardo Lynch, joining us as the face of energy conservation, I am confident that we are going to see an upsurge in the effects that we see from our programmes,” she noted.“Ricardo represents the youth. He is a good role model for our country and he has sound ethical values which we will be promoting,” she added.The 23-year-old cyclist had a successful 2008 season, capturing a silver Medal at the World Cup in Denmark and a Gold Medal at the Moscow Grand Prix. Cycling is the only other sport apart from track and field in which Jamaica has medalled at an Olympic games. Advertisementslast_img read more

Economist Studying Trends in Opioid-Related Deaths in CT, MA

first_imgEconomist Studying Trends in Opioid-Related Deaths in CT, MA UConn researcher Nathan Fiala is studying the connections between economic status and opioid-related deaths in Connecticut and Massachusetts through a USDA Hatch Grant.(Pixabay)The opioid epidemic has been making headlines in America for over half a decade. The death toll from this crisis has steadily been rising since 2015. But there are many questions about who is most at risk of opioid-related deaths that researchers are still working to address.Nathan Fiala, associate professor of agricultural and resource economics in the College of Agriculture, Health, and Natural Resources has received a Hatch Grant from the United States Department of Agriculture to study the correlations between opioid-related deaths, economic factors, and the COVID-19 pandemic.Fiala will take advantage of a massive database cataloguing information about every person who has died in the states of Connecticut and Massachusetts since 2012. The database includes information on the cause of death, the person’s age, race and ethnicity, gender, the last job they held, the town they lived in, and the town they died in.“Those pictures look very different from one another,” Fiala says. “It’s really fascinating.”Existing research on opioid-related deaths has already found significant differences among demographic groups. For example, white men who use opioids tend to die at early middle age whereas black and Latinx men who use opioids tend to die later in life.Fiala is looking to determine where these deaths are happening and to whom. While the database he will be using goes back to 2012, he will be focusing on more recent trends from the past four or five years through present.Fiala suspects his research applying an economic lens to these deaths will reveal a troubling pattern that opioid-related deaths are much more prevalent for lower-income individuals who worked lower-skill jobs and lived in economically disadvantaged areas.This study will provide solid data to back up what has been largely anecdotal common knowledge about the opioid epidemic’s disparate impact on low-income individuals.“We’re quantifying very precise things people have had a suspicion about but didn’t have the best evidence for,” Fiala says.While there has been some research on these trends nationally, Fiala is focusing in on the impact the epidemic is having more locally.“Rather than looking at this nationally, we’re really focusing on two New England states,” Fiala says.Fiala will also be looking about how the COVID-19 pandemic may map onto these trends.This new grant relates to Fiala’s previous work studying the death toll among frontline workers in Connecticut and Massachusetts.He found that the virus disproportionately impacted black and Latinx households and the loss of the primary wage earner in these households had a devastating effect on communities.This work will be useful to stakeholders at all levels of government and nonprofit organizations to better allocate resources to help those most affected by the ongoing opioid crisis.Fiala holds a Ph.D. in economics from the University of California, Irvine. His research interests include development, food security, environment, and political economy. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Agriculture, america, california, Connecticut, death toll, disadvantaged, environment, frontline workers, Government, health, Massachusetts, Professor, resources, United States, university, University of California, University of Connecticutlast_img read more

‘Stranger Things’ star Millie Bobby Brown screams through Lewis Hamilton hot lap

first_imgCreated with Raphaël 2.1.2Created with Raphaël 2.1.2 Lewis Hamilton and Millie Bobby Brown take a selfie ahead of a hot lap around the Circuit of the Americas.  Handout / F1 Trending Videos Trending in Canada RELATED TAGSAMG GTMercedes-AMGMercedes-BenzLuxuryLuxury VehiclesNew Vehicles Millie Bobby Brown is usually pretty cool and calm when the s*** hits the fan—at least, that’s what we understand from seeing her in the hit Netflix original show Stranger Things, in which she plays a child with – spoilers – special powers.However, when you take the demons away and introduce her to Lewis Hamilton and a Mercedes-AMG GT, Millie’s tone changes… slightly.In a video posted a week before the next season of Stranger Things is expected to be released, F1 world champion racing driver Lewis Hamilton decided it would be a good idea to take Ms. Brown out for a spin. See More Videos The Rolls-Royce Boat Tail may be the most expensive new car ever advertisement In the end, it seemed like a couple of Brits having a blast at Circuit of the Americas. Lewis Hamilton currently holds the record for most wins by a driver in the United States Grand Prix. COMMENTSSHARE YOUR THOUGHTS ‹ Previous Next › Buy It! Princess Diana’s humble little 1981 Ford Escort is up for auction An engagement gift from Prince Charles, the car is being sold by a Princess Di “superfan” We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. Due to F1 copyright rules we are not allowed to host the video in this post, but you can head on over to the Formula 1 YouTube page to catch all the action.Despite Millie’s plea to “not go too fast,” Lewis either can’t help himself or doesn’t actually believe he was going that quickly. After a few hot laps and a lot of screaming, Lewis shreds some tires and performs some donuts in the AMG. PlayThe Rolls-Royce Boat Tail may be the most expensive new car everPlay3 common new car problems (and how to prevent them) | Maintenance Advice | Driving.caPlayFinal 5 Minivan Contenders | Driving.caPlay2021 Volvo XC90 Recharge | Ministry of Interior Affairs | Driving.caPlayThe 2022 Ford F-150 Lightning is a new take on Canada’s fave truck | Driving.caPlayBuying a used Toyota Tundra? Check these 5 things first | Used Truck Advice | Driving.caPlayCanada’s most efficient trucks in 2021 | Driving.caPlay3 ways to make night driving safer and more comfortable | Advice | Driving.caPlayDriving into the Future: Sustainability and Innovation in tomorrow’s cars | virtual panelPlayThese spy shots get us an early glimpse of some future models | last_img read more

Tracking airborne pollutants, ozone precursors in Boulder

first_img Published: May 14, 2018 • By Trent Knoss Share Share via TwitterShare via FacebookShare via LinkedInShare via E-mail Preliminary results from an automated emissions monitoring system at the Boulder Reservoir indicate a strong correlation between air quality in the area and oil and natural gas development in neighboring Weld County, with northeasterly winds consistently bringing higher levels of ethane, propane and methane that are not attributable to urban emissions or vehicles.The findings, compiled from thousands of data points taken since April of last year, identify sources of airborne pollutants known as volatile organic compounds (VOCs), ozone precursors that can adversely affect Boulder County’s air quality.In the presence of sunlight, ozone is created through the chemical reaction of VOCs and nitrogen oxides (NOx), causing particularly high levels of ozone pollution during summer months. Ozone levels in the Denver Metro/North Front Range area are above the National Ambient Air Quality Standards (NAAQS) for ground-level ozone as set by the U.S. Environmental Protection Agency (EPA) under the Clean Air Act.  The project, which is sponsored by Boulder County Public Health and led by researchers from CU Boulder’s Institute of Arctic and Alpine Research (INSTAAR) in partnership with the Colorado Department of Public Health and the Environment (CDPHE), installed the first automated system of its kind in the Rocky Mountain region that provides valuable real-time information through hourly postings on a public website for residents and policymakers alike.The researchers have measured methane and NOX on a continuous 24/7 basis using equipment at Boulder Reservoir since mid-February 2017, collecting over 100,000 NOX measurements and almost 35,000 methane measurements in that span. The site has also collected VOCs such as ethane, propane and benzene since early April 2017 in over 4,000 samples. The CDPHE monitors ozone at the Boulder Reservoir concurrently, which provides information for ozone and ozone-precursor VOC and NOX data from the same location.Over the first year of the monitoring operation, wind direction proved to be the strongest predictor of hourly air quality in Boulder. Strong winds from the west tended to carry the fewest pollutants of any samples, while moderate to strong winds from the northeast tend to carry the highest pollutant levels. “The results of this study show the significant negative influence oil and gas facilities from outside the county have on people here in Boulder County,” said Jeff Zayach, Boulder County Public Health Director. “This is a public health concern, especially since the levels of ozone in the county and the Front Range are already so high that it’s causing and contributing to respiratory problems.” “The two most surprising findings are the very clear association between VOC pollution levels and wind direction and the attention that this project has received from residents,” said Detlev Helmig, an associate professor at INSTAAR and the lead investigator of the project.“The data are very clear: oil and gas pollution blowing in from Weld County is undermining public health here in Boulder County,” said Elise Jones, Boulder County Commissioner. “If we are to be successful in our efforts to ensure healthy air for our residents and to meet the Clean Air Act’s ozone standards regionally, these emissions must be dramatically reduced or, better yet, eliminated.” Breathing ground-level ozone causes symptoms such as coughing, throat irritation, pain, burning or discomfort in the chest, chest tightness and wheezing or shortness of breath. Long-term exposure to ozone causes more frequent and severe asthma attacks, increased hospitalizations and higher rates of illness and death.This air monitoring project provides new public insight into which VOCs contribute to ozone formation and in what capacity, providing Front Range residents and lawmakers with crucial information needed to make decisions on policies to reduce ozone levels and meet the national standard.The Boulder Reservoir ozone precursor air quality monitoring is currently funded until September 2018.Categories:EnvironmentNews Headlineslast_img read more

From the Dean of Students: Enjoy your winter break

first_imgDean of Students Sandy JonesIf you’re graduating this week, an added congratulations! I wish you the best of luck in the future. If you are returning after winter break, I also encourage you to spend a few moments to reflect on your past semester. What went well? What classes did you enjoy, and why? What could have gone better? What can you adjust to finish even stronger next semester?Over winter break, many of us will be spending time with family. Reconnecting after time apart from loved ones can bring a sense of feeling grounded and rejuvenated, but it is important to acknowledge it can be stressful, too, especially when we anticipate conflict.I have learned that starting difficult conversations from a place of empathy can help me stay calm and respectful. If you are looking for support, your CU community is here for you, even while you are away. If you have a moment, I encourage you to check out SilverCloud, our online tool and app that supports emotional and mental well-being.I hope each of you can find some time and space over winter break to think about the spring semester ahead and how you can prepare. Consider internship opportunities, your involvements or create a bucket list of things to do before graduation.Take care of yourselves, and I’ll see you in January.Sandy Jones Dean of StudentsCategories:Leadership CornerCampus Community Share Share via TwitterShare via FacebookShare via LinkedInShare via E-mail Published: Dec. 18, 2018 Congratulations, you did it! As we reach the end of finals, be proud of the hard work you’ve done to finish the semester strong. I encourage you all to spend some time over the next few weeks having fun, relaxing and recharging.last_img read more

JDIP Multi-million Dollar Road Rehabilitation Projects Underway in St. Catherine

first_img Issued by: The National Works Agency JDIP Multi-million Dollar Road Rehabilitation Projects Underway in St. Catherine TransportFebruary 16, 2011 RelatedJDIP Multi-million Dollar Road Rehabilitation Projects Underway in St. Catherine RelatedJDIP Multi-million Dollar Road Rehabilitation Projects Underway in St. Catherine RelatedJDIP Multi-million Dollar Road Rehabilitation Projects Underway in St. Catherine FacebookTwitterWhatsAppEmail Major rehabilitative works have commenced on nearly 40 kilometers of roadway in the parish St. Catherine. The works which are valued at nearly one billion dollars are being undertaken along four main corridors. The roads are Tulloch to Zion Hill, Ewarton to Worthy Park, Natural Bridge to Pear Tree Grove and Featherbed Lane. Manager of Communication and Customer Services at the National Works Agency Stephen Shaw says work on the 12 kilometer stretch from Tulloch to Zion Hill, the 10 kilometer road from Ewarton to Worthy Park and the 11 kilometer thoroughfare from Natural Bridge to Pear Tree Grove commenced last month. Featherbed Lane in Spanish Town is also being rehabilitated.  Mr. Shaw says that these projects are slated to be completed within nine months to a year. He says bushing of the road banks, trimming of overhanging trees and drain cleaning activities are all in progress. The works also include the reshaping of the roadways, construction of retaining walls, drainage construction and paving of the thoroughfares with Double Surface Dressing and Asphaltic Concrete. These roads form part of several that have been identified in St. Catherine, for rehabilitation under Phase one of the Jamaica Development Infrastructure Programme (JDIP). Under the JDIP, the NWA has already completed work valued at nearly 100 million dollars in the parish. These include the completion of retaining walls along the Rennals to Point Hill and the Garden Hill to Kentish parochial roads. Similar work has also been completed in the community of Browns Town, which is located along the main road from Bamboo to Worthy Park. Advertisementslast_img read more

Global unit advances Telefonica transformation plan

first_img Luz verde a la fusión entre Telefónica y Liberty Global en el Reino Unido Telefónica refuerza la seguridad de las cadenas de bloques Related Español AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 31 JAN 2020 Tags Yanitsa Boyadzhieva Previous ArticleLG pins mobile hopes on 5G as woes continueNext ArticleTele2 expects imminent green light for Croatia sale center_img Home Global unit advances Telefonica transformation plan Yanitsa joins Mobile World Live as a Reporter based in London. She has more than 5 years’ experience at various media outlets in her home country Bulgaria. She started her career as a political reporter, followed by taking editor roles… Read more Telefonica created a new global unit focused on digitalising sales processes and customer relations, along with driving innovation in the company, as part of a broader transformation plan unveiled late in 2019.The new Chief Digital Consumer Office (CDCO) will be led by Chema Alonso, who was previously responsible for the company’s data strategy and cognitive intelligence project, Telefonica said in a statement.Telefonica’s CDCO will focus on promoting new digital products and services, mainly in the home space, and extending innovation efforts in new customer relationship models through its virtual assistant Aura.Innovation in areas including networks and relationship with the entrepreneurial community will also be in the new division’s scope.Management structureTelefonica said the unit will be managed by a group of experienced professionals, with Francisco Jose Montalvo as chief data officer; David del Val, director of core innovation; Antonio Guzman, responsible for Aura, and digital home products and services; Fabio Bruiggioni as digital consumer director; and Irene Gomez, head of a new Connected Open Innovation network, among others. Subscribe to our daily newsletter Back Telefonica bolsters blockchain security Author digital transformationrestructureTelefonicalast_img read more

Is the INK4a/ARF Overlap a Settled Example of Poor Design?

first_imgBillions of Missing Links: Mysteries Evolution Can’t Explain To me, these reasons do not seem satisfactory for the overlap of INK4a and ARF. The high intrinsic mutation rate of INK4a and ARF appears to be in conflict with the function of these proteins as tumor suppressors. As Szklarczyk et al. write: “From the selection standpoint, it would make most sense to maintain a virtually invariable tumor suppressor.” However, Szklarczyk offers some more tempting explanations for this overlap.  Tagsamino acidsARFbiological informationbiological infrastructurebiologycancerconstraintsdata compressionDNAErika DeBenedictisevolutiongene evolutiongenomeINK4aintelligent designMITmutationsopen reading framesoptimalityoverlapping genesRadek Szklarczyktumors,Trending Photo: Cancer cells, by National Cancer Institute.In three posts so far (here, here, and here), I have been responding to a TedX talk by recent MIT bioengineering PhD Dr. Erika DeBenedictis titled “It’s Time for Intelligent Design.” In my last post, we examined three examples of optimality in core biological infrastructure: development, metabolism, and the amino acid chemical space. Observing optimality in core biological infrastructure should encourage further testing of the optimality hypothesis in peripheral areas of biology. These examples should also caution us about predicting mechanisms of genome architecture we don’t fully understand as “poor design.” Further, if aspects of biology really are optimal then when random mutation disrupts that optimality, human directed intelligent design may be able to step in and revert to the design, restoring optimality. In contrast, if aspects of biology are optimal but, due to a misunderstanding of the system or constraints we interpret it as poor design and seek to reengineer it, then suboptimality may be the result.  “Painfully Embarrassing”? Evolution Email Print Google+ Linkedin Twitter Share Yet one possible benefit of tight coupling between INK4a and ARF may be in the sharing of the 3′-UTR region. The two mRNAs exhibit extraordinary stability, which is thought to be determined primarily by 3′-end sequence elements (43). Another possibility is that the region of overlap may be sustained through evolution to promote variability to eliminate mutants (44). Whereas fragments of the gene (e.g., single coding exons) require high variability, still other fragments may be selected for lower amino acid changing substitutions. In this case, a single mutation in the region of overlap would lead to multiple amino acid substitutions, subsequently invoking an organism’s surveillance mechanisms.(Szklarczyk et al.) While one or none of the above reasons could account for the INK4a and ARF overlap, currently there is not enough research to say for sure. But there is certainly the suggestion of a function for the overlap. This much is clear: in light of the limited current understanding of overlapping genes, it is premature to label the INK4a/ARF overlap as a “dumb mistake.” Instead investigation should continue as to whether this is an example of deleterious information compression, the best solution to multiple conflicting constraints, or maybe a genius way of alerting the surveillance system that there is a problem with that cell’s tumor suppressor genes. In my next post I will highlight why I recommend this cautious approach from a historical standpoint. From the intelligent design perspective, it is easier to explain. This region may be a necessary biological compromise given constraints on the system. Alternatively it could be a deleterious compression of biological information that has occurred post-design, a corrupting of biological information. Or its genius may yet need to be discovered. For added clarity, let’s look at known functions for overlapping reading frames. Origin of Life: Brian Miller Distills a Debate Between Dave Farina and James Tour Known Reasons for Overlapping Reading Frames Indeed, this idea that the INK4a/ARF overlap is a “dumb mistake” is problematic for those committed to evolutionary explanations. According to standard models of gene evolution, genes duplicate and evolve new functions all the time. In this case, if the overlap region really is deleterious, then a duplication of this region, followed by subfunctionalization of one gene in one copy and the other gene in the duplicate, should be able to remove the overlap. At least that’s what standard stories of gene evolution tell us. Even in an evolutionary framework, the fact that the overlap persists would seem to suggest that it’s there for some functional reason and isn’t a harmful or poorly designed property of the genome.  Email Print Google+ Linkedin Twitter Share Dr. DeBenedictis’s basic argument is that there is a section of the human genome where two genes overlap, both of which are important for suppressing tumors. She argues that because of this overlap, a single mutation in the overlap region could disrupt both genes, resulting in two broken or mutated genes as opposed to one. In her view it would be better for the genes to have no overlap, spacing out potentially harmful mutations. However, just because the INK4a/ARF overlap is nonintuitive, that doesn’t mean it isn’t the best possible design. There may be good reasons for the overlap.center_img Emily ReevesEmily Reeves is a biochemist, metabolic nutritionist, and aspiring systems biologist. Her doctoral studies were completed at Texas A&M University in Biochemistry and Biophysics. Emily is currently an active clinician for metabolic nutrition and nutritional genomics at Nutriplexity. She enjoys identifying and designing nutritional intervention for subtle inborn errors of metabolism. She is also working with fellows of Discovery Institute and the greater scientific community to promote integration of engineering and biology. She spends her weekends adventuring with her husband, brewing kombucha, and running near Puget Sound. Share Just because optimality has been observed in some core biological infrastructure, that doesn’t mean all aspects of biology are well designed. At [6:11] Dr. DeBenedictis shares her frustration as an engineer about the overlapping sequence between INK4a and ARF. She calls this a “dumb mistake” and argues: Another function of overlapping genes is to serve as gene nurseries. (Pavesi) Overlapping genes present a puzzle for natural selection as two proteins each subject to selection are encoded in the same stretch of DNA. Selective forces on one protein constrain the evolution of the other. This constraint may actually reduce the sequence search space, allowing for development of a novel gene based on existing genetic information. Interestingly, the evolution of overlapping open reading frames is often asymmetric. That means one protein’s open reading frame acquires non-synonymous changes (affecting the amino acid sequence) while the other acquires mostly synonymous mutations (leaving the amino acid sequence unaffected). This is the case for ARF and INK4a. This area is subject to a high intrinsic rate of mutation but ARF accumulates nearly all the non-synonymous mutations while INK4a is spared. Intelligent Design Is the INK4a/ARF Overlap a Settled Example of Poor Design?Emily ReevesMay 20, 2021, 6:44 AM Tempting Explanations for the Overlap Jane Goodall Meets the God Hypothesis Overlapping genes have received more attention in recent years as intriguing aspects of biological information encoding. (Pavesi) To date, known functions for overlapping sequences include the data-compression hypothesis which states that dual encoding is sometimes required when there is a strong biophysical limit on genome size. (Chirico et al.) Living in the digital age, we exploit the usefulness of data compression each time we compress a raw image or audio file to a JPEG or MP3. We recognize data compression as a necessary trade-off that reduces space and lowers the resources needed to transmit data.  Congratulations to Science Magazine for an Honest Portrayal of Darwin’s Descent of Man Another reason for overlapping reading frames in a single transcript is coupling of transcription and translation. To me this area of the human genome is like painfully embarrassing. Over billions of years of evolution, genomes will accumulate these errors. It’s just heartbreaking because any human engineer would catch this, no one would engineer this deliberately. “A Summary of the Evidence for Intelligent Design”: The Study Guide Recommended A Physician Describes How Behe Changed His MindLife’s Origin — A “Mystery” Made AccessibleCodes Are Not Products of PhysicsIxnay on the Ambriancay PlosionexhayDesign Triangulation: My Thanksgiving Gift to Alllast_img read more

Derry man charged with murder has bail revoked after damaging electronic tag

first_img Google+ Twitter By News Highland – July 10, 2012 A Derry man charged with murder has had his bail revoked over allegations he damaged an electronic tag.Thomas Stokes, of The Old Fort, Strathfoyle, is charged with criminal damage of the tag on July 9.The 22-year-old is currently on High Court bail accused of the murder of John Mongan in Belfast on February 7, 2008.As part of his bail conditions Thomas Stokes is electronically tagged and must abide by a curfew.Derry Magistrate’s Court today heard that police were notified of the damage to the tag by Group 4 Security.They called to Stokes’s home and he claimed the damage, believed to be in the region of £200, was caused while he was in a sauna.An investigating officer told the court Group 4 Security were not happy with this explanation, and would “suggest that if the tag was melting in the sauna so would the skin”.She said police were concerned about Stokes being released on bail because he “may tamper with electronic monitoring equipment, may abscond or not turn up for court”.Deputy District Judge Liam McNally said it was “incomprehensible” damage was caused to the tag in the sauna.He told Stokes he had interfered with the conditions of bail and would be remanded in custody as a result.The 22-year-old will appear in court again via videolink on July 26. Google+ Pinterest Facebook Main Evening News, Sport and Obituaries Tuesday May 25th WhatsApp WhatsApp News Derry man charged with murder has bail revoked after damaging electronic tagcenter_img Pinterest Man arrested on suspicion of drugs and criminal property offences in Derry Facebook RELATED ARTICLESMORE FROM AUTHOR Twitter Further drop in people receiving PUP in Donegal 75 positive cases of Covid confirmed in North Previous articleBeach restrictions at Rossnowlagh and Murvagh liftedNext articleThomas Elvin sentencing deferred for nine days News Highland 365 additional cases of Covid-19 in Republic Gardai continue to investigate Kilmacrennan firelast_img read more