To feed its 1.4 billion, China bets big on genome editing of crops

first_img Gao’s first CRISPR success—her proof-of-principle editing of plant DNA—was with rice, which has a genome one-eighth the size of the one in humans. But she soon tackled wheat, which has six sets of chromosomes and a genome nearly six times larger than the human one. In a tour de force experiment published in Nature Biotechnology in July 2014, Gao’s group showed how either TALEN or the much simpler CRISPR could cripple production of a protein that makes wheat susceptible to powdery mildew, a fungal disease that extensively damages harvests. With conventional breeding, “that would have been a nightmare, if not impossible,” Lippman says, because wheat has six copies of the key gene, and knocking out all of them would have taken multiple generations.CRISPR can easily modify several genes in one step, and it is faster and simpler than TALEN. But CRISPR has its limits: In a paper in the 19 April issue of Science, Gao’s lab showed that one popular CRISPR variation called base editors makes many unintended “off-target” mutations. And although CRISPR efficiently knocks out existing genes, putting many plant traits within its reach, it can’t efficiently add new genes. “We are not so good at it,” Gao says. No one is. Gao notes her lab succeeds only about 1% of the time, but it—and the rest of the plant CRISPR world—is trying to improve those odds.CRISPR researchers are also looking for easier ways to get the components of the genome editor—typically two or more genes—through the tough walls that protect plant cells. For now, scientists depend on cumbersome injection devices known as gene guns or on growing specialized plant-infecting bacteria to deliver the CRISPR apparatus. But China’s new acquisition, Syngenta, may have a more elegant approach. Its North Carolina unit has engineered corn pollen to deliver the CRISPR machinery into cells, where it makes an edit and then disappears. Preliminary evidence, reported in the April issue of Nature Biotechnology, shows the strategy works in wheat and a few vegetable species.Most of all, scientists still need to identify the right genes to manipulate, says geneticist Catherine Feuillet, who previously headed crop science at Bayer and now is chief scientific officer of Inari Agriculture, a startup in Cambridge, Massachusetts. (The firm has licensed Lippman’s technology and he is a consultant.) Changing a single gene to control pests or a fungus has been the “bread and butter of biotech,” Feuillet says, but multiple genes—often unidentified—affect prized traits such as yield, drought tolerance, or the ability to survive without agrochemicals. “The person who can predict that ‘if you do this edit, this is the performance you have’ is the winner of the whole game,” Feuillet says. STEFEN CHOW This story, the first in a series on CRISPR in China, was supported by the Pulitzer Center.BEIJING AND DURHAM, NORTH CAROLINA—If Gao Caixia were a farmer, she might be spread a little thin. Down the hall from her office at a branch of the Chinese Academy of Sciences (CAS) here in Beijing, seeds from a strain of unusually soft rice and a variety of wheat with especially fat grains and resistance to a common fungus sprout in a tissue culture room. A short stroll away, wild tomato plants far hardier than domestic varieties but bearing the same sweet fruit crowd a greenhouse, along with herbicide-resistant corn and potatoes that are slow to brown when cut. In other lab rooms Gao grows new varieties of lettuce, bananas, ryegrass, and strawberries.But Gao isn’t a farmer, and that cornucopia isn’t meant for the table—not yet, anyway. She is a plant scientist working at the leading edge of crop improvement. Every one of those diverse crops has been a target for conventional plant breeders, who have slowly and painstakingly worked to endow them with traits to make them more productive, nutritious, or hardy. But Gao is improving them at startling speeds by using the genome editor CRISPR.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Gao is one face of the Chinese government’s bet that CRISPR can transform the country’s food supply. A natural bacterial immune system, CRISPR was turned into a powerful genome editor just a few years ago in U.S. and European labs. Yet today, China publishes twice as many CRISPR-related agricultural papers as the second-place country, the United States. The explanation? “Because I’m here,” jokes Gao, who punctuates much of her speech with robust, giddy, infectious laughter.In August 2013, her group modified plant DNA with CRISPR, a first, and the 50-year-old researcher has since written three dozen publications that describe using the genome editor on various crops. Daniel Voytas, a plant geneticist at the University of Minnesota in St. Paul who invented an earlier genome-editing system and who has also adopted CRISPR, says Gao is an “outstanding cell biologist [who] jumped on CRISPR early on and has just been riding the crest of the wave.” Syngenta Beijing Innovation Center A researcher who works with Gao Caixia plants CRISPR-modified wheat in a Beijing greenhouse. Gao Caixia and her team grow gene-edited wheat, including strains engineered to resist a common fungal disease, in this experimental station in Beijing. STEFEN CHOW By using CRISPR to disable the gene for an enzyme that degrades the cell wall in fruits, Syngenta is developing an edited tomato (right) that has prolonged shelf life. STEFEN CHOW Did CRISPR help—or harm—the first-ever gene-edited babies? Whatever the outcome of China’s regulatory decision, it won’t address CRISPR’s own limitations, especially for changing crop traits influenced by multiple genes. “We still have to tackle a lot of those challenges,” Voytas says. But he expects China’s major academic and industrial push into CRISPR to pay off in improved techniques as well as new crops. “China definitely has the foundation to contribute and make discoveries on those frontiers, particularly now that such a big investment has been made.”Gao doesn’t have a farming background, and as a teenager she did not dream of becoming a plant scientist. “If I said that, I’d be lying,” Gao says, laughing again.High school students in China take a standard exam, the gaokao, and their performance leads to offers in specific majors at specific universities. “I thought it would be very nice to be a doctor, but I was not really at that level,” Gao says. She was offered a slot at an agricultural university. “I thought that was fine because otherwise I’d be quite embarrassed to go back to high school for another year to take the exam again.”Whatever the downsides of an educational system that puts the country’s needs above individual desires, it has helped build a strong agriculture research community for China. And the nation backs it with money. In 2013, the most recent year for which USDA has comparative figures, China’s public funding of agricultural research approached $10 billion—more than twice what the U.S. government spent—and it supported more than 1100 agricultural research institutes. “I of course need to apply for all my grants, but the percentage of my proposals that get funded seems higher than the rest of the world,” Gao says.Gao did not immediately embrace CRISPR after reading the landmark study in June 2012 that showed how to transform the bacterial system into a tool for altering genomes. Her lab at the time was having steady success with a more cumbersome genome editor, transcription activatorlike effector nuclease (TALEN), the system Voytas invented. “We had knocked out more than 100 genes with TALEN, and we were so proud of it,” Gao says. “And you think, ‘a new technology, arrrgh, should we try it or not?’” Although Gao, Bei, and the rest of China’s CRISPR plant community are ready to unleash a bounty of edited crops, their government first has to clarify its regulatory policies. Many agricultural industry observers think it’s waiting to see how the public reacts in the United States as companies there tiptoe into that future. In February, Calyxt—a Minneapolis, Minnesota, company that Voytas co-founded—brought to the U.S. market the first gene-edited food product, a “healthier” soybean oil created with TALEN that it sells to the food industry. Calyno oil, the company boasts, has zero trans fats, 80% oleic acid, and “three times the fry life and extended shelf life.”Corteva, of Wilmington, Delaware, will likely bring the first CRISPR crop to market, and it, too, is far from one that will help feed the world. Corteva—DowDuPont’s agricultural arm, now rebranded with a consumer-friendly name—deleted a gene in order to improve what’s known as waxy corn, which industry uses to make shiny paper and to thicken food. Neal Gutterson, Corteva’s chief technology officer, says the company hopes its new, even waxier corn will help the public become more comfortable with the concept of CRISPR-altered food. “People don’t like the combination of technology and food in the same sentence, certainly not in the same phrase,” he says.For Corteva, Syngenta, and the other two big ag companies—BASF and Bayer (which acquired Monsanto last year)—the long game is to use CRISPR to develop better versions of their serious moneymakers, the “elite” varieties of a wide range of crops that have big commercial markets. They sell dozens of kinds of elite corn seeds—for example, inbred strains that consistently have high yields or reliable resistance to herbicides. Creating the genetic purity needed for an elite variety typically takes traditional breeding of many generations of plants, and CRISPR is seen as the cleanest way to improve them quickly. The earlier methods of engineering a plant can lead to unwanted genomic changes that must be laboriously culled.The Chinese government signaled it would back modern genome editing of plants in a 5-year plan issued in 2016, and to many observers the purchase of Syngenta confirmed that. “They have had a plan for years now, and I think the Syngenta acquisition was part of that plan at the outset,” says food scientist Rodolphe Barrangou, a pioneering CRISPR researcher who previously headed genomics R&D at DuPont and now is at North Carolina State University in Raleigh. The untold story of the ‘circle of trust’ behind the world’s first gene-edited babies STEFEN CHOW Technicians in a lab run by Gao Caixia pick immature embryos from wheat seeds so they can edit their genomes with CRISPR. But she is far from alone in China. Her team is one of 20 groups there seeking to use CRISPR to modify crop genes. “All the labs use CRISPR for basic research,” Gao says. “They cannot live without CRISPR.” China also expanded its efforts beyond its borders in 2017, when the state-owned company ChemChina bought Switzerland-based Syngenta—one of the world’s four largest agribusinesses, which has a large R&D team working with CRISPR—for $43 billion. That was the most China has ever spent on acquiring a foreign company, and it created an intimate relationship between government, industry, and academia—a “sort of a ménage à trois” that ultimately could funnel intellectual property from university labs into the company, says plant geneticist Zachary Lippman of Cold Spring Harbor Laboratory in New York.Chinese leaders “want to strategically invest in genome editing, and [by that] I mean, catch up,” says Zhang Bei, who heads a team of 50 scientists at the Syngenta Beijing Innovation Center and works closely with a sister R&D facility in Durham. “And they also want to be the global leader as well in this area.”China may one day need CRISPR-modified plants to provide enough food for its massive population, notes rice researcher Li Jiayang, former president of the Chinese Academy of Agricultural Sciences in Beijing and vice minister of agriculture. “We have to feed 1.4 billion people with very limited natural resources,” says Li, who works at the same CAS campus as Gao, the Institute of Genetics and Developmental Biology. “We want to get the highest yield of production with the least input on the land from fertilizers and pesticides, and breed supervarieties that are pest and disease resistant as well as drought and salt tolerant. All this means we need to find the key genes and to work with them.”Before the harvest of that effort can move from labs to farms and tables, however, China needs to resolve how it will regulate CRISPR-engineered crops—a divisive issue in many countries. In a 2018 decision that rocked big agriculture, a European court ruled that such crops are genetically modified organisms (GMOs) that need strict regulation. In contrast, the U.S. Department of Agriculture (USDA) exempts genome-edited plants from regulations covering GMOs as long as they were produced not by transferring DNA from other species, but by inducing mutations that could have occurred naturally or through conventional breeding.Chinese consumers are wary of GM food. The country strictly limits the import of GM crops, and the only GM food it grows are papayas for domestic consumption. But for CRISPR, many plant researchers around the world, Lippman included, assume China will follow in the United States’s footsteps. China’s CRISPR push in animals promises better meat, novel therapies, and pig organs for people Barrangou suggests the Chinese government is reticent about how it will regulate CRISPR-modified plants for strategic reasons. “In terms of gamesmanship, is it not possible that they will make the announcement when they’re ready to give the green light at the same time with their own products?”It’s too soon to say which CRISPR crop Syngenta will try to take to market first if China gives the green light, says Wu Gusui, who heads seed research at the company’s North Carolina facility. “It could be tomato, could be corn, depending on the progress of the next 2 or 3 years.” But he says Syngenta sees CRISPR-modified corn as a big opportunity in China, which grows more hectares of corn than any other crop. Yields per hectare are only 60% of those in the United States because corn ear worms often weaken Chinese crops. A fungus thrives in the weakened plants, producing a toxin that makes the resultant ears unfit for animal feed. As a result, China must import a great deal of corn. (According to USDA, 82% of U.S.-grown corn has been engineered to have a bacterial gene that makes it resistant to ear worms.)CRISPR could allow Syngenta to quickly modify the corn genomes to introduce insect resistance or other traits, bolstering China’s food supply while transforming agribusiness there. The country’s seed marketplace has some 3000 companies, and none has more than a 10% share of corn, Wu says. “Syngenta is putting a lot of emphasis to grow in China to become the leading seed company. The China market as a whole, if it modernizes as the U.S. has modernized, can be as big as the U.S. market.”Gao has her own contenders to be China’s first CRISPR crops: different kinds of aromatic rice—“it’s easy to make and very popular,” she says—and wheat that’s resistant to powdery mildew. Regardless of which crops make it to farmers first, Gao says, they likely will arrive long before any CRISPR-derived medical treatment reaches a doctor’s office or an animal product comes to market. Crops may have a lower profile, but the research also presents fewer risks and ethical dilemmas. Propelled by China’s vast investment, it is also much further along.Just ask Gao. If Chinese regulators do open the door for CRISPR-engineered food, how long would it take before something in one of her culture rooms or greenhouses might be ready for planting on a commercial farm? “Six months,” she says. “That’s why we work with CRISPR.”And Gao doesn’t laugh when she says that. CRISPR in China Read more from our special series. With its CRISPR revolution, China becomes a world leader in genome editing To feed its 1.4 billion, China bets big on genome editing of crops Gao Caixia’s team grows CRISPR-modified rice strains in experimental paddies near its lab in Beijing. By Jon CohenJul. 29, 2019 , 8:00 AMlast_img read more

Facebook Fan Q&A: How to Choose Investments for Your Retirement Plan

first_imgOne of the biggest tests for investors — and, for savvy investors, one of the biggest opportunities — is how they behave when the market gets rocky. There are essentially two things every investor can do when the market suffers a… Full Story,There are a number of reasons why it might be tempting to cash out your hard-earned 401k savings before retirement. From hefty car or home repairs to emergency medical expenses, sometimes unexpected circumstances cause us to seek out extra cash…. Full Story,2018 was a roller coaster for the stock market. If you’re an investor, you were probably impacted more than once – for better or worse. The Dow Jones Industrial Average (DJIA), Nasdaq Composite, and S&P 500 each hit new all-time… Full Story,You’re bound to make a few rookie errors when trying out anything for the first time, whether it’s making homemade greek yogurt, growing heirloom tomatoes, or learning to drive. After all, learning is a process, and trial and error is… Full Story,It’s easy to think of investments as existing in a vacuum. You contribute money, wait a certain amount of time and watch your portfolio grow. Where that money goes – and how it grows – are questions most people would… Full Story,Out of the main pillars of financial wellness—earn, save, spend, invest, and protect—investing can oftentimes feel like the scary, unknown thing lurking in the closet. Being frugal, creating a spending plan, and buying insurance seem to operate within the warm,… Full Story,Getting ahead financially is a game of inches. It’s about finding every trick, tip, and loophole you can find to maximize the growth potential of your money. There’s no topic where the phrase “work smarter, not harder” is more relevant…. Full Story,When you make a mistake in daily life, you usually have the opportunity to immediately make things right. If you spill soda on the floor, you can mop it up. If you burn the chicken you’re roasting for dinner, you… Full Story,One of the precious, oh-so-sweet things you give up when you go freelance is an employer-sponsored 401(k)—along with any matching contributions. But on the flipside, freelancers have quite a few options when it comes to saving for a retirement nest… Full Story,As the VP of Investments at a fintech company, it’s my job to pay close attention to the ever-changing trends and progress within the world of money. Working at Fundrise also means I’m directly involved with the development of the… Full Storylast_img read more

3 Secrets to a Healthy Relationship with Money

first_imgGetting physically fit takes discipline, effort, and more than a little energy to get to where you want to be. Regularly moving your body and sticking to a fitness plan isn’t easy, and doing so is certainly commendable—and comes with… Full Story,Table of Contents Benefits of Working During Retirement Phased Retirement Types of Employment Recommended Jobs for Seniors  Resources for Seniors  Retirement looks different for everyone. Some people dream of playing golf and visiting their grandchildren, while others see it as… Full Story,A study conducted by Charles Schwab just last year found that three in five Americans live paycheck to paycheck, yet only one in four has a written financial plan. In fact, the majority of Americans are hesitant to receive any… Full Story,Life is unpredictable. Some days aren’t all sunshine, like when your car breaks down or your house needs a repair. These situations happen to everyone. That’s why it’s important to save while things are going well, so you can cover… Full Story,Structure is the key to growth. Without a solid foundation – and a road map for the future – it’s easy to spin your wheels and float through life without making any headway. Planning allows you to prioritize your time,… Full Story,Car accidents are not only scary but also a monumental hassle. That’s largely thanks to what comes after the accident itself.   After an accident, you’ll likely have to spend ample time on the phone with your insurer. Then there’s dealing… Full Story,If you’re a furloughed government employee, you are likely feeling a good deal of stress and uncertainty about how to manage your finances during the government shutdown. While missing a paycheck is a financial moment no one wants to experience,… Full Story,Buried underneath paying bills, digging out of a debt hole, and saving for your kids’ college is the marathon of money goals: retirement. Cue the fantasies of spending your days at a leisurely pace, working on The Great American Novel—at… Full Story,When I’m on top of finances, I’m all up in my money management apps, checking my balances and the swift progress I’ve been making on my savings goals. But when things aren’t going so hot? I’m like an ostrich with… Full Story,With all of today’s home-based tech gadgets and virtual personal assistants, smart homes are quickly becoming ubiquitous. And with high demand for connected products, so too comes ease of use, accessibility and affordability.   But as with all expenses, it’s important… Full Storylast_img read more

If You Have Left-Side Abdominal Pain, Here’s What It Could Mean

first_imgAbdominal pain is one of the top reasons people seek medical treatment—and no wonder: It could be anything from a pulled muscle to a life-threatening aneurysm.Identify the type of pain“Abdominal pain is a common symptom that leads to millions of outpatient visits, and is, in fact, one of the most common reasons for people to see a doctor,” says Rosario Ligresti, MD, Chief, Division of Gastroenterology at Hackensack University Medical Center. If the pain came on suddenly and is so severe that the patient goes to the emergency room, says Dr. Ligresti, then a doctor may run specialized diagnostic x-ray tests, including a CT scan. While serious conditions such as ruptured aortic aneurysm, an aortic tear, perforated or twisted bowel, and low blood flow conditions to the bowel (ischemia) may require emergency surgery to correct, many other conditions can be safely evaluated in the doctor’s office.Locate the painWhen determining the cause of left-side abdominal pain, the doctor will first find the exact location, explains Dr. Ligresti. If the pain is mostly in the upper left of the abdomen, it could be stomach or kidney causes like indigestion, gas, reflux, gastritis, ulcers, and kidney stones, he says. If it is in the left lower abdomen, doctors tend to think of colon conditions (diverticulitis and colitis), gynecologic causes (ovarian cysts or endometriosis), or testicular conditions. In addition to pain, a doctor will look for fever, bloody stools, persistent nausea and vomiting, weight loss, or change in urination. “We also want to know if the pain is associated with numbness, burning, tingling or itching of the skin, or if there are any skin rashes (especially blisters) over the area,” says Dr. Ligresti.DiverticulitisThe American Gastroenterological Society defines diverticulitis as inflammation of the pockets (diverticula) in the wall of the colon. “Diverticulitis is one of the most common sources of left lower abdomen pain and classically presents with associated fever, change in bowel habits, sometimes bloody stools, chills, and fairly localized symptoms,” says Dr. Ligresti. In serious cases, diverticulitis can lead to bleeding, tears, or blockages. Diagnosing the condition requires a physical exam and imaging tests. “This is an important diagnosis to make since it requires treatment with antibiotics right away,” says Dr. Ligresti.ColitisWhile the abdominal pain associated with diverticulitis often occurs suddenly, the symptom of colitis (inflammation of the colon) appear more gradually. “Also, colitis tends to present with changes in bowel function (diarrhea or bloody diarrhea) and diverticulitis usually does not,” says Dr. Ligresti. Colitis is often caused by infections (such as from food poisoning), poor blood supply, and autoimmune reactions. There are also different types of the condition, including Crohn’s disease and ulcerative colitis, a type of inflammatory bowel disease. GastritisThis term is a catchall for conditions that involve inflammation of the lining of the stomach. The inflammation can be due to an infection, regular use of pain relievers, or drinking too much alcohol. Symptoms of gastritis may happen suddenly (acute gastritis) or occur slowly (chronic gastritis) and in some cases, gastritis can lead to ulcers. Ulcers and gastritis are one of the most common causes of left upper abdominal pain and typically present with a deep, gnawing pain that may get worse at night and then improve after eating, explains Dr. Ligresti. These conditions can also often be associated with nausea and vomiting, weight loss, and dark stools. “This is an important diagnosis to make since treatment is very effective if started early,” he says.ShinglesIf you’ve had chickenpox, the virus—varicella-zoster—can lie dormant for decades before returning as shingles.People often mistake the symptoms for another illness, according to the National Shingles Foundation. If your left-side abdominal pain comes with skin symptoms like a rash, numbness, or burning, your doctor will need to test for shingles, says Dr. Ligresti.Abdominal aortic aneurysmThis is a scary one because the aorta is a major blood vessel that supplies blood to the body, explains Gina Lynem, MD, physician consultant at Blue Cross, Blue Shield of Michigan. An abdominal aortic aneurysm (AAA) means a wall of the aorta is bulging, and it often grows slowly without symptoms; a burst AAA is life-threatening. “As an abdominal aortic aneurysm enlarges, some people may notice a pulsating feeling near the navel, deep constant pain in the abdomen or on the side of your abdomen, or back pain,” she says. Every year, 200,000 people in the U.S. are diagnosed with an abdominal aortic aneurysm, according to the Society for Vascular Surgery. “If you have any of these symptoms, you should see your physician immediately,” says Dr. Lynem.IndigestionWe all know the feeling of discomfort, feeling too full after eating, bloating, a burning sensation in your gut, and belching. Also known as dyspepsia, indigestion can result from underlying issues with diet, anxiety, reaction to medications, pregnancy, or disease, explains Dr. Lynem. There are a variety of over-the-counter medicines available to treat indigestion, but often evaluating and changing your diet is the most effective course, she says. Ovarian cystsThe ovaries are located in the lower abdomen on both sides of the uterus. Some women experience ovarian cysts, fluid-filled sacs that develop on the ovaries, but usually they’re painless and go away on their own. “Many women won’t even realize they’ve had one,” says Dr. Lynem. “However, in some cases, they can trigger pelvic pain.” If the pain is sharp, accompanied by fever, dizziness, or rapid breathing, it may indicate a ruptured cyst or ovarian torsion; both need immediate treatment. While there is no way to prevent an ovarian cyst, they can be detected during a routine pelvic examination or through ultrasound. Kidney stonesKidney stones occur when pieces of the hard mineral deposits that build up naturally in the kidney break off and enter your ureter, explains Dr. Lynem.”In addition to abdominal pain, you’ll likely notice urinary symptoms such as discomfort, discoloration, a foul smell, or persistent need to empty the bladder,” she says. According to the National Kidney Foundation, more than a half-million people go to emergency rooms for kidney stone problems every year. Kidney stones are caused by not drinking enough water, exercise (too much or too little), obesity, weight-loss surgery, or eating food with too much salt or sugar. “The best way to prevent and get through the pain of a kidney stone is to stay well-hydrated,” says Dr. Lynem.Pulled or strained abdominal muscleLifting, twisting, doing too many sit-ups or crunches, and even hard coughing or sneezing can strain an abdominal muscle: “A pulled abdominal muscle or abdominal strain most commonly results from overstretching or over-exercising,” says Dr. Lynem. “It will feel like a cramp that could also involve acute pain, bruising, swelling, or spasms.” The best way to recover is to rest and apply a cold pack for comfort, she says.Pelvic inflammatory diseasePID is an infection and inflammation of a woman’s pelvic organs, including the uterus, fallopian tubes, ovaries, and cervix. You can treat it with antibiotics, explains Dr. Lynem. Sexually active women under the age of 25 are at highest risk for developing PID. According to the Centers for Disease Control, PID is often caused by untreated sexually transmitted diseases (STDs), and one out of eight women with PID will experience difficulty getting pregnant. “Pelvic inflammatory disease may not produce any symptoms, but in other cases, it can cause abdominal or pelvic pain, fever, vaginal discharge, painful urination, or painful sexual intercourse,” says Dr. Lynem.GasBurping, flatulence, bloating, and pain or discomfort in your abdomen are all symptoms of gas—a normal part of the digestive process. Most people pass gas 13 to 21 times per day. “Gas is typically not painful, but it can be annoying and embarrassing,” says Dr. Lynem. Gas is most often caused by swallowing air (from chewing gum or eating or drinking too fast) or when bacteria in the large intestine break down certain foods that are prone to cause gas. “Diet is often to blame for an increase in gas,” says Dr. Lynem. People with certain conditions such as celiac disease, irritable bowel syndrome, or an intolerance to lactose or fructose are also more likely to experience gas.HerniaThe most obvious symptom of a hernia is a bulge or lump in your abdomen that results from an organ pushing through an opening in muscle or other tissues, explains Dr. Lynem. According to the Cleveland Clinic, there are several types of hernia, but the most common (representing 75 to 85 percent of the cases) are inguinal: The intestine or the bladder pops through the abdominal wall or the groin. You may be able to push the lump or bulge back in, or it may disappear when you lie down, but activities such as crying, laughing, coughing, or physical activity can push the lump back out—and it can be painful. Other symptoms of a hernia include a dull aching sensation, feeling full, and pain when lifting objects. “A doctor should be consulted for a specific treatment plan that may or may not require surgery,” says Dr. Lynem.Intestinal obstructionThis is a partial or complete physical blockage of your small or large intestine that prevents routine digestion, explains Dr. Lynem. Common causes include scar tissue resulting from surgery, hernia, and tumors; symptoms can include pain, bloating, and loss of appetite. “Treatment varies, depending on the source and severity of the blockage, but a blockage can be severe enough to require a hospital stay and even surgery, so be sure to seek immediate treatment if you are not passing any gas or stool,” says Dr. Lynem. If you don’t get treatment, your intestine can rupture—and that can be deadly.Sourcelast_img read more

How to Create Clickable Links in SlideShare Presentations [Quick Tip]

first_img Topics: Don’t forget to share this post! AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to Email AppEmail AppShare to LinkedInLinkedInShare to MessengerMessengerShare to SlackSlack This situation sound familiar? You’re clicking through a SlideShare and stumble upon a call-to-action (CTA) that reads, “Click here to learn more!” You’re intrigued, so you click the blue, hyperlinked text … then nothing happens. Ugh.As a user, you think “How careless of them to forget to include the link!” But chances are, most marketers creating SlideShares aren’t even aware these links are broken. They’ve done their due diligence by hyperlinking links in PowerPoint, exporting the file to a PDF, and uploading the file to SlideShare. The problem is, when you save a PowerPoint file as a PDF, unfortunately, hyperlinked text doesn’t get carried over. Ugh.Lucky for marketers, there’s an easily solution for adding links to SlideShare presentations on both Mac and PC. You’ll be raking in the clicks to your other content in no time — and your users will be much happier for it. Here’s how you can create clickable links in SlideShare:PCTools You’ll Need: PowerPoint and Adobe Acrobat Pro (free trial)Step 1: Hyperlink the text box or object you want to make clickable.Be sure you’re not hyperlinking the text itself — this process won’t work if you do.Step 2: Paste the hyperlink into the address box.Step 3: Click ‘File,’ then ‘Save as Adobe PDF.’Step 4: Save the PDF.Step 5: Once the PDF publishes, you will have a clickable link within your presentation. Step 6: Upload the hyperlinked PDF to SlideShare, and voila: clickable links within slides!MacTools You’ll Need: PowerPoint and Adobe Acrobat Pro (free trial)Step 1: Save your PowerPoint file as a PDF.Step 2: Go to the folder where your file is saved in Finder. Right click on the PDF, then select ‘Open with Adobe Acrobat Pro.’Step 3: Find the slide you want to hyperlink in the PDF. Click ‘Edit,’ then ‘Edit Text & Images.’Step 4: A pane will pop up on the right side of the window. Under ‘More Content’ click ‘Add or Edit Link.’Step 5: Click and drag your cursor over the object you would like to hyperlink (a translucent box will appear as you drag). An options box will appear. Select ‘Invisible Rectangle’ under ‘Link Type’ and ‘Open a web page’ under ‘Link Action.’ Then, click ‘Next.’Step 6: Enter the URL for the link in the dialogue box, then click ‘OK.’ You now have a clickable link in your PDF. Don’t forget to save before exiting!Step 7: Upload the PDF to SlideShare, and your hyperlinked slides will automatically be clickable.Ta-da! Clickable SlideShare links without too much trouble. How will you use clickable links in SlideShare to boost your marketing efforts?Image Credit: Mykl Roventine Presentations Originally published Jul 9, 2013 2:23:35 PM, updated July 28 2017last_img read more

13 Non-Technical Ways to Make Your Computer Run Faster

first_imgIf your computer is constantly cursed by the spinning wheel of death, or you feel like you’re using a 90’s Netscape browser to surf the web, fear not — it doesn’t necessarily mean you need a new computer.You can implement some simple fixes to make your computer run faster, and most of them only take a few minutes to complete. Let’s flesh them out below.13 Non-Technical Ways to Make Your Computer Run FasterCheck your hard disk spaceCategorize desktop icons into foldersSave old pictures and videos to the cloud or an external hard driveClose unused tabsUninstall unused programsDelete temporary filesStop programs from automatically launching when your computer turns onRemove unnecessary language resourcesUpdate your computer’s softwareIf your computer is hot to the touch, let it cool downShut down or restart your computer at least once a weekRemove unused dashboard widgets or gadgetsDelete browser extensions or plugins you don’t use Topics: Productivity 1. Check your hard disk space. A common rule of thumb to keep your computer running fast is to have at least 15% of its hard disk space free. If your hard disk is almost full, you need to remove some programs and files to improve your computer’s speed. But if your disk has plenty of room, there could be something wrong with your operating system.2. Organize desktop icons into folders. Organizing desktop icons into folders cleans up your background, and it also cuts down your computer’s RAM usage. Your computer has to load each individual icon when you don’t organize your desktop, which takes up a lot of RAM space. If each icon is in a folder, then your computer only needs to load each folder.3. Save old pictures and videos to the cloud or an external hard drive. If you have old pictures and videos on your computer that you rarely look at but don’t want to delete, transfer them to the cloud or an external hard drive. You’ll save a ton of memory on your computer and improve its speed.4. Close unused tabs.Sometimes, you need to keep a bunch of tabs open to complete an important project — but if you’re done looking at a web page, it’s best to close it. Unused tabs on internet browsers hog a ton of memory and slow down your computer.5. Uninstall unused programs.Most computers have pre-installed programs that you’ll never use, but even though you’ve never opened them, they slow down your computer by using up memory, wasting a ton of disk space, and running background processes. Be careful not to remove any programs you don’t recognize, though. They could be crucial for the function of your computer or other applications.6. Delete temporary files.Temporary files like internet history, cookies, and caches take up a ton of space on your hard disk. Deleting them frees up valuable space on your hard disk and speeds up your computer.On Mac OS X, you can download CCleaner to find and delete temporary files in your hard disk. To delete temporary files on Windows, you can run a disk cleanup, which you can access by clicking Start > All Programs > Accessories > System Tools > Disk Cleanup.7. Stop programs from automatically launching when your computer turns on.If you can’t justify Spotify launching every time you turn on your computer, consider stopping it from happening. Programs that automatically launch and keep running eat up a lot of your computer’s memory.To remove the items that automatically launch on OS X, click the Apple icon, navigate to Systems Preferences, then to Users & Groups, and finally to Login Items. Here, you’ll see all the programs that automatically launch when your computer starts, and you can uncheck each one.On Windows, click the Start menu, search for “msconfig”, and then click on the Startup tab. A list of programs will pop up, and you can uncheck the ones you don’t want automatically launching.8. Remove unnecessary language resources. Each default language on your computer uses a ton of resources and files that devours free space on your hard disk. To remove any unused languages on OS X, download Monolingual. To remove them on Windows, go to Settings > Time & Language > Region & Language, click on the languages you don’t use, and, finally, click Remove.9. Update your computer’s software.Updating your computer’s software can be a drag, but it’s definitely worth it: new software updates fix bugs and glitches that slow down your computer. To check if your current software is up-to-date on a Mac, go to Apps under the Apple icon menu and click on Updates. On Windows, click the Start Button > All Programs > Windows Update > Check for Updates.10. If you can scramble an egg on your computer, give it a break. A constantly overheated computer will eventually turn into a sluggish computer. If your laptop is hot to the touch, it’s working too hard and you need to let it cool down. To ventilate your computer, point a fan at it and use it on a flat surface, so air can properly flow underneath it.11. Shut down or restart your computer at least once a week. When you leave your computer on, background programs and applications hog its memory. Shutting down or restarting your computer refreshes your memory and prompts important tools to run maintenance on it. As a general guideline, shutting down or restarting your computer at least once a week will help speed it up.12. Remove unused dashboard widgets or gadgets. Dashboard Widgets on OS X and Gadgets on Windows devour RAM space because they run background updates, even when you’re not using them. You can use Widget Manager on OS X to delete these space-wasters. And on Windows, all you have to do is right click and uninstall the Gadgets you don’t use.13. Delete browser extensions or plugins you don’t use.Browser extensions and plugins are some of the most convenient applications on the internet. But installing too many can slow down your web browser’s speed — especially if you forgot about most of them. To help boost your browser’s speed, uninstall the extensions or plugins that you don’t use anymore.center_img Originally published Jun 21, 2018 7:00:00 AM, updated June 21 2018 Don’t forget to share this post!last_img read more

13 Influencer Marketing Campaigns to Inspire and Get You Started With Your Own

first_img1. Sprint: #LiveUnlimitedInfluencers: Lele Pons, Gerard Adams, Prince Royce, Bradley Martyn, Rachel CookNot only did Sprint cause Verizon’s famous “can you hear me now?” guy to switch to Sprint, but the company has collaborated with musicians, entrepreneurs, and actors to gain the attention of a massive young audience.Its latest influencer campaign uses the hashtag #LiveUnlimited, and features people who have massive social media presences. The best part is these people naturally embody the appearance and lifestyle of #LiveUnlimited. Elite Daily founder Gerard Adams and internet personality Lele Pons are just two of them.Sprint introduces all five influencers (listed above) in this video ad:2. Old Navy: Boys & Girls Club of AmericaInfluencer: Alex RodriguezOld Navy is a veteran of influencer marketing, having partnered with fashion and lifestyle bloggers all over Instagram to promote various lines of Old Navy clothing. For Black Friday, the company doubled down on this strategy by partnering with New York Yankee retiree Alex Rodriguez to raise money for the Boys & Girls Club of America (BGCA). Being an alumnus of the BGCA, Rodriguez’s promotion helped Old Navy raise $1 million as part of sales during Black Friday alone.As a proud @BGCA_Clubs , I’m excited to help @OldNavy in their goal to donate $1 MILLION to Boys & Girls Clubs this holiday season.This Fri only, for every $1 pair of Cozy Socks you buy in-store, @Oldnavy donate $1 to @BGCA_Clubs — up to 1M! #Ad— Alex Rodriguez (@AROD) November 19, 20183. Fiji Water: BodyworewhatInfluencer: Danielle BernsteinYou know the water brand, Fiji, but you might know its campaign partner better by the Instagram name, weworewhat.Danielle Bernstein’s fashion blog, We Wore What, recently joined Fiji Water to create Bodyworewhat, an influencer marketing campaign offering eight-minute workout videos with Bernstein and personal trainer Eric Johnson.This campaign was meant to demonstrate Fiji’s commitment to hydrating those who want to look and feel as fit as Bernstein, while helping her fans get there with all the right motivators. Influencer Marketing You can’t go anywhere these days without hearing about the elusive, purportedly mystical powers of influencer marketing.But is this buzzword-laden tactic actually worth your time and energy?According to a recent study comprised of marketers from a variety of industries, 94% said influencer marketing was an effective campaign strategy. That’s great news for marketers — right?Not so fast. Even though a majority of marketers believe influencer marketing is a viable tactic, it’s still incredibly challenging to report accurately on influencer campaign ROI. In fact, 78% of marketers said that determining the success of influencer marketing campaigns would be a top challenge this year.Download Our Guide to Influencer Marketing EssentialsSo even though the tangible benefits of influencer marketing — follower engagement, driving traffic, and creating more authentic content — seem clear-cut, there’s still a lot of progress to be made in making this form of campaign measurable for agencies and marketers.Influencer MarketingInfluencer marketing is designed to tap into an existing community of engaged followers on social media. Influencers are specialists in their niches. These individuals have influence over an audience you might be trying to reach, and can be helpful marketing to those buyers.Let’s back up for a minute. How exactly do you perform influencer marketing, and how does it differ from the traditional celebrity spokesperson advertising model?There is some overlap between celebrity endorsements and influencer marketing campaigns. But fans of influencers trust that their endorsement of a product or brand comes from a well-researched, more holistic place, rather than something as simple as a signed contract between a brand and a person of influence.And while there is often a formal agreement in place between both parties, influencers tend to be more selective about their affiliations, choosing to partner with brands that reflect their unique personal brands and won’t alienate their followers.With that in mind, here are four things you need to keep in mind when launching an influencer marketing campaign:Expertise: Would the content of your campaign be appropriate coming from this influencer, given what he or she is famous for?Reach: Can this influencer engage your audience? Does she specifically have reach on the social media channels where your audience spends its time?Demographic: Is this person’s following similar to your company’s buyer persona? Does he or she affect the same people?Notoriety: Is this influencer well liked? Is his/her fame split between admiration and condemnation, or are they a person of mass appeal? (The latter is what you want, so as to not alienate potential customers.)In other words, celebrity product endorsements are less about engagement and more about attaching a person’s fame and name recognition to a particular brand — regardless of who specifically follows their career. For brands, this type of campaign is much more about grabbing the attention of a wide audience than tapping into a very specific niche.To give you an idea of how brands — both big and small — are leveraging the power of influencers in their marketing efforts, we’ve put together a list of ten influencer-driven campaigns. Check them out below and decide for yourself: Is influencer marketing worth the hype?Influencer Marketing ExamplesSprint: #LiveUnlimitedOld Navy: Boys & Girls Club of AmericaFiji Water: “Bodyworewhat”Kaikatsu Club: NETCafe VRH&M: Fall Studio CollectionSperry: Boat Shoes on InstagramSamsung: Note 7 LaunchDiageo: My Tales of WhiskeyGAP: Styld.byStride Gum: Mad Intense GumNaked Juice: Sponsored Instagram PostsLoeffler Randall: LR AmbassadorsGlossier: Regular Women Don’t forget to share this post! Originally published Jul 16, 2019 9:00:00 AM, updated July 16 2019 12. Loeffler Randall: LR AmbassadorsInfluencers: Creative BusinesswomenHigh-end accessory and footwear brand Loeffler Randall has become a favorite among artists, bloggers, and fashion insiders, thanks in big part to the company’s commitment to involving social media influencers in its marketing campaigns.The brand’s “LR Ambassadors” include a diverse group of writers, painters, florists and other creative businesswomen “leading dynamic lives.” In the brand’s own words, their LR Ambassadors are “cool girls doing cool things.”In addition to profiling its LR Ambassadors on the company blog, Loeffler Randall shares pictures of its ambassadors wearing LR shoes and accessories on Instagram, using the hashtag #LRambassador.13. Glossier: Regular WomenInfluencers: All WomenThis Manhattan-based beauty startup (which was recently named one of Fast Company’s Most Innovative Companies of 2017) owes much of their seemingly overnight cult status to their ever-expanding network of super fans and micro-influencers — those people who may have high influence, but low individual reach.Instead of paying a few big names to promote their minimal skincare and cosmetics, the brand relies on “regular women” to spread the word.”What’s very motivating to us is this idea of every single woman being an influencer,” Glossier CEO Emily Weiss told Quartz. Glossier recently introduced a referral program to enable its more influential followers to offer product discounts and other incentives to their unique networks.center_img 6. Sperry: Boat Shoes on InstagramInfluencers: Sperry EnthusiastsToward the end of 2016, the boat shoe brand, Sperry, began working with more than 100 micro-influencers on Instagram to create engaging content for its followers. Sperry identified fans of the brand on Instagram who were already sharing high-quality photos of its products, and started inviting these users to develop visual content for its official Instagram account. 4. Kaikatsu Club: NETCafe VRInfluencer: EnakorinNot all influencers are based in sports, fashion, or entertainment — not in Asia, anyway. The cafe chain, Kaikatsu Club, recently launched a virtual reality feature across its Japan locations, where customers can play various VR video games while enjoying a drink or a meal. And who better to help spread the word than Japan’s popular TV personality and cosplayer, Enakorin.Enakorin is well known by fans of anime, a Japanese artform responsible for many comics and TV shows across the country. Enakorin is also known for her love of video games, making her a perfect choice to represent Kaikatsu’s new VR entertainment platform. Both of them teamed up with TimeLine Japan on YouTube to talk about it.5. H&M: Fall Studio CollectionInfluencers: Julie Sariñana, Ela VeldenH&M has one of the largest Instagram followings of any fashion brand on social media today, due in large part to its influencer campaign with women who reflect H&M’s style all by themselves.Fashion blogger Julie Sariñana and model Ela Velden are two influencers with whom H&M partnered for its fall 2017 catalogue. Sariñana loved the clothing so much, she promoted it from her own Instagram account: Topics: 7. Samsung: Note 7 LaunchInfluencer: CyreneQNew smartphones are unveiled everyday. So, when Samsung released its Note 7 in 2016, it set out to make sure people knew about it. The company partnered with CyreneQ, a professional Snapchat artist and designer with a huge subscriber base, to broadcast its launch to a mobile audience that it wanted buying its new product.Cyrene used her Snapchat account to document her journey to the event and ultimately give her audience a sneak peak of the new device. Using Snapchat’s 10-second video format, she posted clips showing her followers some of the device’s new features. See how CyreneQ’s Snapchat designs look for the brands she’s worked with here.8. Diageo: My Tales of WhiskyInfluencer: Nick OffermanDiageo, the parent company of Scottish whiskey brands Lagavulin and Oban, was awarded a Shorty Award for Best Influencer Marketing Campaign for this yule log video starring Parks and Recreation’s Nick Offerman.The 44-minute video shows Offerman sitting by a crackling fireplace, staring broodingly into the camera, and occasionally savoring a sip of his drink. Thanks to the simple seasonal premise and Offerman’s unique brand, the video was a viral hit.9. GAP: Styld.byInfluencers: Refinery29, Celebrity BlogsGAP’s successful campaign featured a number of influential social media personalities from blogging giants like Refinery29 and WhoWhatWhere, showing how they incorporate GAP clothing into their personal wardrobes. Users viewing the influencers’ posts on social media were given options to “Shop this Look” conveniently in the caption of photos.Thanks to the involvement of multiple influencers from different niches, GAP’s campaign had enormous reach.10. Stride Gum: Mad Intense GumInfluencer: DJ KhaledIf anyone has figured out how to gain a loyal following on Snapchat, it’s hip-hop artist and producer DJ Khaled. Once a minor figure in the music world, Khaled has enjoyed an unprecedented level of success on the ephemeral photo-sharing app, with each of his snaps garnering over 3 million views on average.”DJ Khaled has completely cracked the platform,” said Emmanuel Seuge, senior vice president for content at Coca-Cola, one of Snapchat’s major advertisers. “He’s the king of Snapchat.”His “King of Snapchat” status means Khaled is in high-demand for influencer campaigns with brands. He regularly takes part in “Snapchat takeovers,” where a brand hands over the reigns of their corporate Snapchat to Khaled for a brief period of largely unfiltered antics.Working with W+K London, Stride Gum launched a Snapchat takeover campaign with Khaled last year to promote its “Mad Intense Gum” campaign. The brand called the takeover “an unpredictable, fun day for all his followers.”Source: W+K London11. Naked Juice: Sponsored Instagram PostsInfluencer: Kate La VieThis bottled smoothie brand is edging its way into the beauty, fashion, and health scene on Instagram with help from key influencers in the space. Lifestyle bloggers like Kate La Vie (below) share sponsored posts featuring snapshots of their daily outfits and beauty essentials — including a strategically placed Naked Juice in the mix.last_img read more

Bring the beard back: Sania Mirza trolls Yuvraj Singh’s ‘chikna chamela’ look

first_imgAfter former India crickter Yuvraj Singh posted a clean-shaven picture of himself on Instagram, he received a flurry of hilarious comments, including one from Indian tennis ace and Yuvraj’s friend Sania Mirza.In the picture posted, Yuvraj Singh unvieled his “chikna chamela” look with a pouted face and asked his fans if he should continue with the same look.In the comment section, the fans suggested Yuvraj Singh to get his beard look back. However it was Yuvraj’s friend Sania Mirza who left the most hilarious comment.”Are you pouting to hide the chin under the chin we spoke bout ???? Bring the beard back,” Sania commented.After announcing his retirement from international cricket, Yuvraj Singh has been quite vocal about the current India team.Recently, the former all-rounder suggested India can try split captaincy if the team management feels there is too much workload on Virat Kohli who is currently leading the side in all 3 formats in international cricket.Yuvraj Singh backed Rohit Sharma to lead India in the shorter formats, given his success in Indian Premier League over the years. However, the batting superstar said it’s up to to the team management to make the call if they are considering the workload of the world’s best batsman.Yuvraj Singh also joined in the ongoing debate on India Test opener where he recommended to pick Rohit Sharma as a Test opener and give him opportunities to settle down at that position.advertisement”If you ask me, Rohit Sharma should have opened in Tests from the beginning of his career. You play him one match and then drop him and say Rohit Sharma is not scoring runs in Test cricket. How can you expect someone to perform without giving him 10 Test? Now if you are making Rohit Sharma open in Tests, you should give him 6 Tests and tell him Rohit, you have got 10-12 innings, go and play your game, nobody will say anything,” Yuvraj told Aajtak in an exclusive interview.Also Read | Based on Virat Kohli’s workload, India can try a different captain for shorter formats: Yuvraj SinghAlso Read | Rohit Sharma should’ve opened in Tests from the beginning: Yuvraj SinghAlso Seelast_img read more

Not interested in keeping wickets in Test: Mushfiqur Rahim informs Bangladesh coach

first_imgFormer Bangladesh captain Mushfiqur Rahim has decided to give up his wicketkeeping duties in Test cricket to focus solely on batting and prolong his career.Mushfiqur, who has made 67 Test appearances in his career so far and has 103 catches and 31 stumpings to his name, feels he has too much on his plate. Mushfiqur represents Bangladesh in all three formats and continues to play in domestic T20 leagues.Mushfiqur Rahim has informed head coach Russell Domingo about his decision to quit wicket-keeping in the longest format of the game, and Bangladesh coach reportedly agreed after consulting other members of the team management.”I am not interested to keep wickets in Test. Now there are lots of games in the upcoming days and I play in all formats. Apart from international cricket, I play in DPL [Dhaka Premier League] and BPL [Bangladesh Premier League]. Considering everything, I think it is getting a bit overloaded,” he said.”I want to perform for a long time and because I am playing across formats I needed to think. I did not have any severe injury during the last five years but at the same time, I did not take a substantial amount of rest. In the future, such scenarios should not arise that I have to take rest in one or two series.”So instead of that [missing series for rest] the only thing that I can do is minimize my workload and that is only possible by not keeping in Test and that’s why I have taken this decision.”advertisementMushfiqur has scored 3,515 runs at an average of 37 in 55 Test matches where he kept the wickets for Bangladesh. In the remaining 12 Test, his average drops down to 24.47 in which he was not a designated wicket-keeper. However, he now feels that he cannot give his best with the bat if he continues to keep wickets.last_img read more

Mi TV 5 series key features confirmed by Xiaomi ahead of November 5 launch

first_imgXiaomi will launch a number of products across categories on November 5. The launch event will take place in Beijing, China. One of the many products that will be announced on the slated date (Nov 5) is the Mi TV 5. The company is expected to launch more than one Mi TV under the upcoming Mi TV 5 series. Ahead of the launch, the company has revealed some of the key details about the Mi TV 5 series.Xiaomi has confirmed that the Mi TV 5 series will come with 12nm T972 chipset paired with 4GB of RAM and 64GB storage. The 12nm T972 chipset is said to come with 8K video recording. The new 12nm chipset is said to be almost 63 per cent more powerful when compared to the previous generation chipsets.Earlier this week Xiaomi confirmed that the upcoming Mi TV 5 series will sport a 4K QLED panel. Having said that the Mi TV 5 series will be the first TV series from Xiaomi to come with QLED panel. All the previous generation Mi TVs either come packed with LCD or LED display.Days before the launch the company also confirmed that the Mi TV 5 series will feature Samsung’s Quantum Dot panel that will offer NTSC 108 per cent wide colour gamut. This clearly means that the Mi TV 5 series will offer better multimedia and viewing experience to the users when compared to the previous generation Mi TVs with LCD/LED panel.Ahead of the launch the company also shared a teaser of the Mi TV 5 series. The teaser shows the upcoming Mi TV from the side. The image reveals that the Mi TV 5 will be one of the slimmest TVs that Xiaomi has ever launched. The teaser photo also revealed that the Mi TV 5 series will include the “Designed by Mi” logo on the side on the side of the TV. For now, no further details of the Mi TV 5 have been revealed by the company.Xiaomi supposedly wants to take on the likes of recently launched OnePlus TV series with the Mi TV 5 series. OnePlus recently launched the OnePlus TV Q1 and the OnePluS TV Q1 Pro in India. Xiaomi is yet to reveal details about the Mi TV 5 series India launch.ALSO READ | Mi CC9 Pro leaks reveal everything before launch: Full specs, live images, camera details, and morelast_img read more

The Big 12 Looks Different, and Gundy is Now an Elder Statesman

first_imgKansas StateBill SnyderBill Snyder202 West VirginiaDana HolgorsenDana Holgorsen46 OklahomaBob StoopsLincoln Riley0 BaylorArt BrilesMatt Rhule0 Three years ago. That’s not that long. It’s less than 1,100 days. Thirty-six measly months ago, Art Briles was the coach at Baylor, Bob Stoops was the coach at OU, Paul Rhoads was the coach at Iowa State, Charlie Strong was the coach at Texas and Charlie Weis was the coach at Kansas. Now, all those schools have different leading men with a combined five wins at their current schools.And the big three — Baylor, OU and Texas (which have won or shared 12 of the last 13) Big 12 titles — have coaches who have a collective 0 wins at those schools. That’s astonishing, but it also points to something else: In a year when change has suddenly become en vogue, Oklahoma State now has maybe the best, most proven coach in the entire conference in Mike Gundy (he and Bill Snyder are the only two coaches in the league with outright Big 12 titles).This year begins an era of transition with the announcement of Bob Stoops’ retirement as the Texas and OU coaches’ combined age is less than Snyder’s. The Red River Rivalry will look different. Bedlam will look different. Baylor-TCU will look different. The whole thing is unrecognizable from three years ago.The last time the Texas-Oklahoma football game had 1st-year coaches for both schools was 1947: Blair Cherry for Texas; Bud Wilkinson for OU.— Brad Townsend (@townbrad) June 7, 2017 SchoolCoach in 2014Coach in 2017Wins by coach Iowa StatePaul RhoadsMatt Campbell3 While you’re here, we’d like you to consider subscribing to Pistols Firing and becoming a PFB+ member. It’s a big ask from us to you, but it also comes with a load of benefits like ad-free browsing (ads stink!), access to our premium room in The Chamber and monthly giveaways.The other thing it does is help stabilize our business into the future. As it turns out, sending folks on the road to cover games and provide 24/7 Pokes coverage like the excellent article you just read costs money. Because of our subscribers, we’ve been able to improve our work and provide the best OSU news and community anywhere online. Help us keep that up. TexasCharlie StrongTom Herman0 Here is a look at the coaching turnover in the last three years at all 10 Big 12 schools including wins at current school by each coach. It should be noted that Patterson and Gundy are two of the three longest-tenured CFB coaches at the same school (and Snyder would lead that by a wide margin if he didn’t retire for a few years in the mid-2000s).One crazy aside: Of the 10 current head coaches in the Big 12, seven (!) are at the only place they’ve ever been a head coach (and the other three have a combined 3 wins at their current schools). Wild. KansasCharlie WeisDavid Beaty2 Oklahoma StateMike GundyMike Gundy104 TCUGary PattersonGary Patterson149 Texas TechKliff KingsburyKliff Kingsbury24 All of this appears to mildly tilt the short-term scales towards Oklahoma State, Kansas State, West Virginia and Texas. We know what we’re getting with the first three, and Herman has at least done this at a pretty high level at a pretty mediocre school. With Lincoln Riley, we think we know — Stoops thinks he knows — but the reality of a 33-year-old taking over in Norman is pretty incredible. Maybe he’ll be awesome (with Baker Mayfield this year, he probably will), but that’s not even close to a sure thing.The Big 12 is going to be volatile for the next few years until we figure out what we have with Herman and Riley. Will OU still be really good in 2017? Probably, but I think everyone is sort of underrating how good Stoops was and how difficult it is to steer that ship. Dan Wetzel wrote about this for Yahoo and what the big picture looks like for the Big 12.Which, after Wednesday’s surprise retirement by Oklahoma coach Bob Stoops, means it may not be an overstatement to say the future of the league rests in the hands of two coaches who have never led a team at the Power Five level. Neither man owes anything to anyone other than their players and their school, but the stakes for college football are considerable.The league’s other members can have, and have had, great success. Everyone knows however that the league needs its national brands, Texas and Oklahoma, to serve as the glue for both membership and the collective ability to generate hundreds of millions in revenue. That’s just the reality of business – no matter how strong TCU or Oklahoma State or Baylor has been on the field. [Yahoo]Now I don’t care as much about the big picture for the Big 12 as I do about how it affects Oklahoma State, but his point remains. There is a lot of unknown in the league right now which is great for Mike Gundy and Co. Or at least it is right now. You’ll take a known commodity at the level OSU has been producing at over an unknown any day of the week. Maybe Herman and Riley will crush and Oklahoma State’s position as the No. 2 power in the conference will be in jeopardy. Maybe they’ll move to No. 3 instead of No. 1.Or maybe Snyder will retire, Holgorsen, Kingsbury and Patterson will keep pumping 7- 8- and 9-win seasons, and Riley and Herman will flail. And Oklahoma State will run the league for the next five years. It’s at least in the realm of possibility which is not something you could say this time yesterday.last_img read more

Adam Schefter Reveals Why Top Prospect Might Not Know He’s Drafted

first_imgAdam Schefter on the phone.NEW YORK, NY – SEPTEMBER 11: Sports Writer Adam Schefter attends the Annual Charity Day Hosted By Cantor Fitzgerald And BGC at the Cantor Fitzgerald Office on September 11, 2013 in New York, United States. (Photo by Jeff Schear/Getty Images for Cantor Fitzgerald)The NFL draft sits just under two hours away and we’re no closer to knowing who the No. 1 overall pick will be.Kyler Murray is the favorite to go No. 1 to the Arizona Cardinals, but Nick Bosa and Quinnen Williams have gained on the former Oklahoma star, according to Vegas odds.While those three names will likely be the first three called on Thursday night, another college football player might not even know he’s been drafted.A deadly tornado ripped through Louisiana on Thursday and damaged the Louisiana Tech campus. Several of the school’s facilities were damaged and the town of Ruston is in recovery after the devastating storm.As a result, top NFL prospect, and former Louisiana Tech Bulldog, Jaylon Ferguson won’t be attending the draft this weekend.Instead, he’s helping the community rebuild.Louisiana Tech defensive end Jaylon Ferguson is helping people in Ruston, La. after the tornado there, and because there’s no cell service, may not know if he’s drafted on Friday, when he is projected to be a second-round pick.— Adam Schefter (@AdamSchefter) April 25, 2019With cell tower service down, Ferguson might not know he’s been drafted by a team.The star pass rusher is expected to be selected in the second round of the draft, but he won’t hear his name called.The NFL draft kicks off on Thursday night at 8:00 p.m. ET. Will Kyler Murray be the No. 1 overall pick or will the Cardinals surprise the NFL world?Stay tuned.last_img read more

Tsunami relief funding benefited from media spotlight – UN official

Briefing the press in New York on the one-month anniversary of the South Asia quake, Jan Egeland said several factors had helped the tsunami relief funding drive, including broadcasts around the world and the fact that the disaster occurred right before the start of a new budget year.”If we had had more images from more tourists of the actual earthquake and how it fell on the children and on the people, of how people were drowned in rubble, I think we would have seen more outpouring,” he said.Meanwhile, UN officials at the Geneva-based UN International Strategy for Disaster Reduction (ISDR) said children could help their elders escape disaster, as exemplified by the case of a school girl who, during the tsunami, applied her knowledge and warned people away from the mammoth tidal wave.Tilly Smith, a British girl who was vacationing in Thailand last December when the tsunami struck, remembered the early warning signs of from a recent geography lesson, alerted her parents, and managed to clear the beach, reportedly saving the lives of over a hundred people.More than anything, Tilly’s story highlighted the critical importance of basic education in preventing the tragic impacts of natural calamities, ISDR officials said.Tilly had just studied the warning signs of a tsunami when she noticed them emerging on the beach in Phuket. “I remembered because I had been taught it in a geography lesson and it was the exact same froth like you get on a beer. It was sort of sizzling,” she said. read more

EHF CUP favorite Rhein Neckar Lowen to win the trophy in Nantes

RHEIN NECKAR LOWEN (77%, 72 Votes)TVIS HOLSTEBRO (13%, 12 Votes)HBC NANTES (7%, 7 Votes)FA GOPPINGEN (3%, 3 Votes)Total Voters: 94Semi-finals:HBC Nantes – TVIS Holstebro 15.45Rhein Neckar Lowen – FA Goppingen 18 Rhein Neckar Lowen is the most serious candidate to win the EHF Cup F4 in French Nantes! That is the major opinion of visitors. Exactly 73% of our fans think that German team will win the first ever EHF Cup F4 tournament. About 12% have opinion that Danish TVIS Holstebro is able to beat HBC Nantes in the semi-final and make serious contender for the trophy. Third team is host – HBC Nantes (7%), while Frisch Auf Goppingen has the smallest chances with only 3% of your votes.Who will win the EHF CUP F4 2013? EHF Cup F4frisch aufhandball matchesHBC NantesholstebroNantesRhein Neckar LowenTVIS Holstebro ← Previous Story Portugal: FC Porto Vitalis defeats Benfica in direct duel for the title and are crowned champions Next Story → Denmark Finals: Aalborg with huge +8 travels to return game against KIF Kolding read more

Its going to get cold but will it snow

first_imgMET ÉIREANN IS warning that this week will see wintry showers with sleet and snow.Temperatures will plummet to below freezing tonight as the country moves well and truly into winter.Showers will start hitting the country today, growing tonight, with strong winds also expected.Tomorrow will be much the same, as showers continue to be scattered across the country. Wednesday will see heavier showers over much of the country, with freezing fog and severe frost expected for later in the week.However, we are due to get off lightly. Britain is forecast to be hit with up to six inches of snow in the next week.And, despite reports last week predicting a white Christmas, Met Éireann says that, scientifically, “it is not possible to make any confident forecast of the coming winter”.Read: Severe storm and tornadoes threaten Midwestern US statesRead: Irish Air Corps capture great shots of wintery Skellig Islandslast_img read more

DISH Network Buys Blockbuster

first_imgAiling movie rental chain Blockbuster has a new owner–DISH Network swooped in and bought the once mighty company, bidding around $308 million. The price, which is likely to work out to around $228 million in cash, beat out bids by Blockbuster shareholder Carl Icahn, SK Telecom in South Korea, and a team of Blockbuster lenders headed by Monarch Alternative Capital.A hearing to approve the acquisition will be held on Thursday. DISH, for its part, expects the whole thing to close by the end of the second quarter of this year. The deal is contingent on a number of factors, including approval from a bankruptcy court.From the sound of it, DISH is in the deal primarily for brand name recognition. From the company’s sales EVP, Tom Cullen, With its more than 1,700 store locations, a highly recognizable brand and multiple methods of delivery, Blockbuster will complement our existing video offerings while presenting cross-marketing and service extension opportunities for DISH Network.While Blockbuster’s business faces significant challenges, we look forward to working with its employees to re-establish Blockbuster’s brand as a leader in video entertainment.last_img read more

Deadlocked jury in Bill Cosbys sexual assault trial ask for definition of

first_img Friday 16 Jun 2017, 7:33 PM No Comments Jun 16th 2017, 7:33 PM By AFP Deadlocked jury in Bill Cosby’s sexual assault trial ask for definition of “reasonable doubt” If convicted, the actor could face spending the rest of his life in prison. Share2 Tweet Email 9,778 Views THE DEADLOCKED US jury battling to reach a verdict in Bill Cosby’s sexual assault trial asked the judge to define “reasonable doubt” and again asked to hear from the fallen star’s testimony.The 79-year-old pioneering black actor could face spending the rest of his life in prison if convicted on three counts of aggravated indecent assault against 44-year-old Andrea Constand at his Philadelphia mansion in January 2004.Yesterday the 12-member jury told Judge Steven O’Neill that they were deadlocked, but the Pennsylvania judge ordered them to continue with no cut-off point to stop trying to reach a unanimous agreement.They have now been deliberating more than 40 hours on whether or not Cosby should be convicted of drugging and molesting Constand. Andrea Constand, right, returns to the courtroom at the Montgomery County Courthouse during Bill Cosby’s sexual assault trial Source: EDUARDO MUNOZ ALVAREZUnder US law, any application of the term “reasonable doubt” would mean that the jury should acquit the defendant.The panel also asked to hear excerpts from Cosby’s deposition in 2005 in which he says he gave the sedative Quaaludes to a woman in Las Vegas in 1976 before having sex with her, and that he used them with other women.The agonizing wait for a verdict saw tensions rise outside the court in Norristown, just outside Philadelphia today.A woman heckled Cosby shouting “shame on you” as he walked into the building while supporters of the actor told her to “shut up” and welcomed him with his “hey, hey, hey” catchphrase from his 1970s and ’80s “Fat Albert” cartoon. Actor Bill Cosby’s supporters outside of Montgomery County Courthouse Source: Van Tine Dennis/ABACAAlthough the trial concerns only Constand’s allegations, 60 women have publicly accused the legendary entertainer of being a serial sexual predator in remarkably similar accusations that span four decades.The trial marks a steep fall from grace for an entertainer known for his role as a lovable father and obstetrician on hit TV series “The Cosby Show.”The avalanche of allegations have already ended the career and pulverized the reputation of a comedy legend who turns 80 next month.If the seven-man, five-woman panel ultimately fail to reach a verdict, O’Neill will be forced to declare a hung jury, leaving open the prospect of a re-trial.Read: Bill Cosby jury have announced that they are deadlocked> Image: Matt Slocum Image: Matt Slocum Short URL Tweet thisShare on FacebookEmail this articlelast_img read more

H7N9 lOMS estime possible que le virus grippal se transmette entre hommes

first_imgH7N9 : l’OMS estime possible que le virus grippal se transmette entre hommesSelon l’OMS (Organisation mondiale pour la Santé), le virus de la grippe aviaire H7N9 pourrait potentiellement se transmettre d’homme à homme. Étant donnée la dangerosité du virus, les études pour mettre au point un nouveau vaccin sont plus que jamais actives.Aucun nouveau cas de grippe aviaire H7N9 n’a été recensé depuis le 8 mai. Pas de quoi décourager les nombreux chercheurs qui, de par le monde, travaillent à la mise au point d’un vaccin. D’autant que la dangerosité de ce virus n’est plus à prouver. Comme le rapporte l’OMS dans son dernier rapport du 17 mai, quatre nouvelles morts sont à imputer au H7N9 (ce qui porte à 36 le nombre de décès sur 131 cas enregistrés, soit 27 %).À lire aussiMaladie de Charcot : symptômes, causes, traitement, où en est on ?Tout en estimant que la transmission du virus d’homme à homme est possible, l’OMS indique qu’il n’existe aucune preuve permettant de l’affirmer avec certitude. Toutefois, un récent rapport conjoint de l’OMS et de la Chine indique que le virus H7N9 présente un plus grand potentiel de transmission d’homme à homme que n’importe quel autre virus de la grippe aviaire.Un virus difficile à cerner L’OMS rappelle également la difficulté à identifier les réservoirs de H7N9 en raison des faibles symptômes qu’il entraîne lorsqu’il infecte la volaille. De plus, même s’il n’y a pas eu de nouveau cas depuis deux semaines, l’OMS précise qu’on ne peut pas considérer que l’épidémie est sous contrôle. Les autorités chinoises en sont même à attendre l’apparition de nouveaux malades, raison pour laquelle la surveillance épidémiologique étroite est maintenue dans le pays.Côté vaccin, quatre sont actuellement en cours de développement. Des chercheurs américains sont même à pied d’œuvre pour mettre au point un vaccin qui pourrait protéger contre plusieurs souches virales à la fois, y compris le H7N9, donc. Le plus intéressant avec un tel vaccin serait sa capacité à continuer à être actif même si le virus venait à muter. Enfin, le vaccin permettrait de produire des anticorps mais aussi des globules blancs (lymphocytes T) capable de tuer le virus et les cellules infectées.Le 21 mai 2013 à 19:04 • Maxime Lambertlast_img read more

‘Game of Thrones’ Stars Are Freaking Out Over Their Emmy Nominations

first_imgCarice van Houten (Melisandre) was also excited about her first Emmy nomination, and shared an uplifting post on Instagram about her Outstanding Guest Actress announcement. “This summer is hot and full of surprises,” she wrote on Instagram. “Wow, I’m very excited and proud!”The 71st Primetime Emmy Awards will air on Sunday, September 22, at 8:00 p.m. EDT on Fox.More on‘Game of Thrones’ Recreated in 300-Foot Embroidered TapestryCreepy Australian Bee Fly Is Named After Night King From ‘Game of Thrones’Exclusive: We Learn More About New ‘Game of Thrones’ Mobile Game Gwendoline Christie (Brienne of Tarth), another first-time Emmy nominee, was shocked about her Supporting Actress announcement and uploaded it to Instagram. Christie wrote, “I CANT BELIEVE IT!!!!!!????!?!!?!!!!!!!!! THANK YOU UNIVERSE!!!!!!!!!!!!!!!!!!! #EmmyAwards #CANITTRULYBEREAL??????????”Maisie Williams— Maisie Williams (@Maisie_Williams) July 16, 2019What do we say to the God of Death? Not today. Maisie Williams (Arya Stark), who was previously nominated for Supporting Actress in 2016, posted a hilarious GIF on Twitter in response to her second Emmy nomination.Sophie TurnerPhoto Credit: Sophie Turner / Instagram“I’m beyond humbled. I truly never thought that this would ever happen,” Sophie Turner, who received her first Emmy nomination for playing Sansa Stark on Game of Thrones, said in her Instagram Story on Wednesday. “This is the best farewell to the show that has been my life for the past 10 years.”Carice van Houten ‘Game of Thrones’ Targaryen Prequel Series Is Reportedly Coming to HBO‘Game of Thrones’ Star Kit Harington Joins Marvel’s &#… Game of Thrones has ended its watch, however, the HBO series is not falling off the radar: For its final season, Game of Thrones recently received 32 nominations for the Emmy Awards, breaking the Emmys record for the most nominations in a single season.Many of the show’s stars, including Alfie Allen, Lena Headey, and Gwendoline Christie, were in complete shock over their Emmy nominations on Tuesday, Variety reported. Many cast members, including Emilia Clarke and Kit Harington, received nominations for lead roles, while others, such as Carice van Houten and Sophie Turner, were celebrating their first Emmy nominations.Game of Thrones squad members posted emotional responses to the epic news on Instagram and Twitter and some said they were “not expecting that” and “thank you universe,” Harper’s Bazaar noted.Alfie AllenPhoto Credit: Alfie Allen / InstagramAlfie Allen (Theon Greyjoy), who was nominated for his first Emmy, wrote on his Instagram Story, “Wow. Was not expecting that.” He then uploaded a picture of goosebumps on his arm to show that he was very excited about the news.Lena Headeycenter_img Stay on target Cersei Lannister died in the Red Keep, but the character’s legacy lives on: Lena Headey, who was nominated for Supporting Actress, posted a funny reaction on Instagram that said, “No I’m not engaged I’m just super CHUFFED and shocked and FULL of gratitude for the game changing opportunity that has been ‘Game Of Thrones’…. what a way to say Adios to this adventure of a lifetime .. Congrats to our INCREDIBLE CREW AND CAST.”Gwendoline Christielast_img read more